Ph partition hypothesis ppt
D rug p k a lipophilicity & g i ph according to ph partition theory the process of absorption of drug compounds of molecular weight greater than 100 daltons transported across the biomembrane by passive diffusion depend upon the following factor dissociation constant of the drug i. , pka of the drug lipid solubility of the unionized drug i. parenterally administered drugs are secreted directly into the gastric juice. the concentration ratio ( concentration of drug hypothesis in gastric juice divided by concentration in plasma) depends on the dissociation constant of the ph partition hypothesis ppt drug. thus strong acids appear in gastric juice in negligible concentration weak bases in measurable amount , weak acids stronger bases in highest concentration. ph partition theory often doesn' t hold true for most weak acids, which are well absorbed from the small intestine. quaternary ammonium compounds are ionized at all ph' s but are readily absorbed from the gi tract. ph range in git • the ph range in git from 1- 8 that of the stomach is from 1- 3 of the intestine ( from duodenum to colon) 5- 8, then certain generalization regarding ionization , absorption of drugs can be made as predicted from ph partition hypothesis. lipophilicity and drug absorption • the gi cell membrane are essentially lipoidal.
effect of particle size dissolution rate on bioavailability of drugs: e ffect of particle size, ph- partition hypothesis , ph- partition hypothesis dissolution rate on bioavailability of drugs presented by j. keerthi priya ( y11mph18006) i/ ii m. pharmacy ( pharmaceutics) sims college of pharmacy m angaldas n agar guntur. brodie proposed the ph partition theory to explain the influence of gi hypothesis ph drug pka on the extent of drug transfer drug absorption. • ph partition theory of drug absorption is based on the assumption that the git is a simple lipid barrier to the transport of drugs and chemicals. accordingly the unionized. 5 factors affecting drug absorption physicochemical factors : 1) drug solubility & dissolution rate 2) particle size & effective surface area 3) polymorphism & amorphism 4) pseudoploymorphism ( hydrates/ solvates) 5) salt ph partition hypothesis ppt form of the drug 6) lipophilicity of the drug ph- partition- hypothesis 7) pka of drug & gastrointestinal ph 8) drug stability. ppt ph - partition theory. for a drug to cross a membrane barrier it must normally be soluble in the lipid material of the membrane to get into membrane, also it has to be soluble in the aqueous phase as well to get out of the membrane.
most drugs have polar non- polar characteristics , are weak acids bases. contents of the powerpoint on ph partition theory include: introduction ph- partition theory drug pka gastrointestinal ph lipophilicity drug absorption deviations from the ph partition theory a unifying hypothesis conclusion references drug absorption: drug absorption is defined as the process of movement of unchanged drug from the site of administration to systemic circulation. view ph partition hypothesis ppts online safely virus- free! many are downloadable. learn new and interesting things. get ideas for your own presentations. share yours for free! dark web research paper.
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